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By: X. Sigmor, M.B.A., M.D.

Associate Professor, Campbell University School of Osteopathic Medicine

The main active ingredients in cannabis are the tetrahydrocannabinols (THC) antibiotics given for pneumonia buy discount ultreon online. These are the chemicals that cause the main effects on the brain and although the most prevalent is the D9 THC antibiotics for acne inflammation buy cheap ultreon 500mg, there are many others that add to the effect antibiotic guide pdf order ultreon with visa. Different forms of cannabis come from different parts of the plant and have different strengths. It is mostly imported from Morocco, Pakistan, the Lebanon and Afghanistan. It is also cultivated in the UK, sometimes on a large scale to sell but sometimes by individuals in their homes or greenhouses for their own use. In the UK the drug is usually smoked rolled into a cigarette or joint, often with tobacco. The herbal form is sometime made into a cigarette without using tobacco or it can also be smoked in a pipe, brewed into a tea or cooked into cakes. Of course, the fibre of the cannabis plant is non-psychoactive and hemp has a long history, being used to make rope, mats, clothing, cooking oil, fuel and varnishes. Cannabis is the most widely used illegal drug in the UK and easily the illegal drug most likely to have been tried by young people. Probably over 5 million people have used it at least once and many people are regular users. It is not surprising that cannabis is the most-seized drug and that the large majority of court cases involve this drug. Others are very much against the idea on both health and moral grounds but the former view has been taken by many police forces who now no longer prosecute those found with small amounts of the drug. There are many issues to debate, few of which have been discussed in detail in the UK. Currently, there is discussion of the medical aspects of the pharmacology of cannabis. There are suggestions, based on anecdotes, animal studies or pressure group opinions, that the drug can be useful to treat glaucoma, in the control of the muscle spasms that are one of the symptoms of multiple sclerosis and for appetite stimulation in cases of chemo- and radiotherapy. The status of cannabis is such that doctors cannot prescribe smokable cannabis to their patients, although synthetic THC preparations (nabilone) are available for nausea. There is growing pressure on the British government to change the law so that the required controlled clinical studies on the potential effects of cannabis can be carried out. A particular restriction on cannabis (and opium) is the offence of allowing your house (or any other premises you have responsibility for) to be used for growing cannabis or smoking it. These maximum penalties are only rarely imposed except where there is very large-scale supplying or trafficking. Most prison sentences for cannabis possession and small-scale supply are less than one year. Effects/risks Smoking cannabis causes a number of physical effects including increased heart rate, decreased blood pressure, bloodshot eyes, increased appetite and mild dizziness. The effects are rapid in onset and start within a few minutes and may last several hours depending on how much is taken. When eaten the effects are slower in onset but then DRUG DEPENDENCE AND ABUSE 509 longer in duration. Eating cannabis may mean a large dose is taken at once, making it difficult to avoid any unpleasant reactions. Cannabis has a mild sedative effect, not unexpected with the receptors for this drug being inhibitory.

Treatment usually involves the injection Submucosa of massive doses of antibiotics antibiotic mrsa generic 100 mg ultreon fast delivery, and perhaps peritoneal intubation (insertion of a tube) to permit drainage antibiotics for acne and alcohol purchase ultreon 500mg on-line. The relatively thick submucosa is a highly vascular layer of con- nective tissue serving the mucosa bacteria yeast best buy for ultreon. Absorbed molecules that pass Extensions of the parietal peritoneum serve to suspend or through the columnar epithelial cells of the mucosa enter into anchor numerous organs within the peritoneal cavity (fig. In addition to The falciform (fal'sı˘-form) ligament, a serous membrane rein- blood vessels, the submucosa contains glands and nerve plexuses. Functions of the greater omentum include storing fat, cushioning visceral organs, sup- The tunica muscularis is responsible for segmental contractions porting lymph nodes, and protecting against the spread of infec- and peristaltic movement through the GI tract. In cases of localized inflammation, such as appendicitis, inner circular and an outer longitudinal layer of smooth muscle. It includes neurons and ganglia from both the sympathetic and parasympathetic divisions of the ANS. The peritoneal cavity provides a warm, moist, normally aseptic environment for the abdominal viscera. In a male, the peri- toneal cavity is totally closed off from the outside body environment. Digestive System © The McGraw−Hill Anatomy, Sixth Edition Body Companies, 2001 638 Unit 6 Maintenance of the Body Falciform ligament Lesser omentum Liver Gallbladder Stomach Liver Stomach Duodenum Parietal Transverse Transverse peritoneum colon colon underneath Descending colon Ascending Greater colon omentum Sigmoid colon Cecum (a) (b) Liver Lesser omentum Transverse Pancreas Greater colon Stomach omentum Duodenum Mesocolon Jejunum Transverse Jejunum colon Greater Mesentery Mesocolon omentum Mesentery Parietal Descending peritoneum Ileum Ileum colon Visceral Rectum peritoreum Sigmoid Vagina colon Urinary bladder (c) (d) FIGURE 18. Digestive System © The McGraw−Hill Anatomy, Sixth Edition Body Companies, 2001 Chapter 18 Digestive System 639 Tunica muscle muscularis muscle Exocrine gland in submucosa FIGURE 18. Vomiting, and in certain cases diarrhea, are reac- tions to substances that irritate the GI tract. Vomiting is a reflexive re- The outer serosa completes the wall of the GI tract. It is a bind- sponse to many toxic chemicals; thus, even though unpleasant, it ing and protective layer consisting of loose connective tissue cov- can be beneficial. Innervation of the Gastrointestinal Tract The body has several defense mechanisms to protect against The GI tract is innervated by the sympathetic and parasympa- ingested material that may be harmful if absorbed. The acidic environment of the stomach and the lymphatic system kill many thetic divisions of the autonomic nervous system (see fig. A mucous lining throughout the GI tract serves as a The vagus nerves are the source of parasympathetic activity in Van De Graaff: Human VI. Digestive System © The McGraw−Hill Anatomy, Sixth Edition Body Companies, 2001 640 Unit 6 Maintenance of the Body the esophagus, stomach, pancreas, gallbladder, small intestine, and upper portion of the large intestine. The lower portion of the large intestine receives parasympathetic innervation from spinal nerves in the sacral region. The submucosal plexus and myen- teric plexus are the sites where preganglionic neurons synapse Transverse palatine folds with postganglionic neurons that innervate the smooth muscle of of hard palate the GI tract. Stimulation of the parasympathetic neurons in- creases peristalsis and the secretions of the GI tract. Palatine uvula Postganglionic sympathetic fibers pass through the submu- Pharyngo- cosal and myenteric plexuses and innervate the GI tract. The ef- palatine arch fects of sympathetic nerve stimulation are antagonistic to those of parasympathetic nerve stimulation. Sympathetic impulses in- hibit peristalsis, reduce secretions, and constrict muscle sphinc- ters along the GI tract. List the four tunics of the GI tract and identify their major tissue types. MOUTH, PHARYNX, The opening of the oral cavity is referred to as the oral orifice, AND ASSOCIATED STRUCTURES and the opening between the oral cavity and the pharynx is called the fauces (faw/se¯z).

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There were many reasons for this increase antimicrobial zinc gel purchase ultreon 500mg without prescription, including the landmark article published in November 1987 in the Wall Street Jour- nal entitled “Lax Laboratories: The Pap Test Misses Much Cervical Cancer Through Labs Errors antibiotics used for cellulitis discount ultreon 250 mg with visa,” which alerted the public to the fact that a Pap smear may be falsely negative antibiotic 6 month old buy discount ultreon 100mg line. The article implied that false- negative Pap tests resulted largely from carelessness. This led to pas- sage of the Clinical Laboratory Improvement Act of 1988 (CLIA 88) that legislated comprehensive regulation of the gynecologic cytology laboratory. Subsequently, there was extensive media coverage of women dying from cervical cancers that had been “missed” on prior Pap smears because of “laboratory error. This was reinforced by CLIA 88 that required review of all prior negative Pap smears in the 5 years preceeding a new diagnosis of a high-grade squamous intraepithelial lesion (HSIL) or carcinoma. Thus, a frequent scenario leading to a Pap smear claim involved a false-negative smear “discovered” upon review of prior “negatives” in a woman diagnosed with cervical carcinoma. To put the potential magnitude of this problem in perspective, a study by the College of American Pathologists (CAP) of the 5-year “look back” at previous negative Pap smears following the diagnosis of HSIL/carcinoma found that 10% of prior smears were false-nega- tives for squamous intraepithelial lesion (SIL)/carcinoma (1). If atypi- cal squamous cells of undetermined significance (ASC-US) were included, 20% of prior smears were false-negatives. In 1996, the American Cancer Society predicted 15,700 new cases of cervical can- cer and 4700 deaths. Published studies indicated that 60 to 75% of women dying from cervical cancer either never had a Pap smear or had not had one in the 5 years prior to diagnosis (2,3). Therefore, if one assumed that 40% of the predicted new cases of cervical carcinoma had a single Pap smear in the prior 5 years with a 20% false-negative rate, there was a potential for 1256 new claims for failure to diagnose cervical carcinoma on a Pap smear in 1996 alone! Table 1 Pap Smear/Cervical Cytology Claims, Includes Pathology and Lab Experience Pathology Case Incurred % of Total Path/Lab Experience Report Allocated Mature Frequency Year Claims Indemnity ALAE Severity Claims Indemnity ALAE Exposures Claims (per 100 Docs) 1991 & Prior 66 4,219,200 1,395,335 85,069 13 17 18 1992 14 203,000 156,377 25,670 10 3 7 1590 14 0. The difficulty was aggravated by the fact that Pap smears had long been a “loss leader” for large independent laboratories attempt- ing to gain market share and was reimbursed well below cost by many health insurers, Medicare, and Medicaid. Combined with the deterio- rating liability climate, this caused many laboratories to consider no longer accepting Pap smears. At stake was the survival of the Pap smear as an effective, affordable, widely available screening test for cervical cancer, as well as the future of cytology as a diagnostic dis- cipline. An additional concern was the effect managed care might have on Pap smear liability. Would the trend toward mandating lab test referral to large regional laboratories (their lower marginal costs associated with large Pap smear volumes helped to ameliorate poor reimburse- ment) interfere with pathologist–physician communication and follow- up cytologic/histologic correlation? Would the frequent patient change of plans and doctors interfere with appropriate Pap smear follow-up? What would the impact be of shifting the responsibility for collecting Pap smears and the appropriate follow-up of abnormal results from gynecologists to primary care physicians? Would the frequency of the annual screening Pap smear be reduced by the pressures of cost contain- ment and diminish the opportunity to detect lesions “missed” on prior false-negative Pap smears? At TDC, physician consultants and panels of medical experts peri- odically meet to review claims from each medical specialty as part of malpractice risk management and loss prevention. In an attempt to manage the escalating frequency of Pap smear claims, a panel com- posed of cytology experts and gynecologists met in 1996 to discuss liability issues involving cervical cytology. The panels’ written rec- ommendations (4) were distributed to all insured pathologists, gyne- cologists, and primary care physicians and presented at state and national professional society meetings. LIMITING PAP SMEAR LIABILITY: PANEL RECOMMENDATIONS An Annual Pap Smear is Important An ideal screening test is one that is always abnormal in the presence of disease, that is, it has a sensitivity of 100%. False-positive results are Chapter 13 / Pap Smear Litigation 171 acceptable and are detected by subsequent specific (and expensive) testing. False-negatives are undesirable because patients with disease will be missed.

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Sometimes clinical information is presented sequentially: the case unfolds in a simulation of real time virus brutal plague inc ultreon 250 mg with visa, but the subject is given few or no options in data collection (for example15–17) antibiotic wound ointment order 250 mg ultreon. The analysis may focus on memory organisation antibiotic resistance frontline proven 100mg ultreon, knowledge utilisation, data interpretation, or problem representation (for example3,17,18). In other studies, clinicians are given all the data simultaneously and asked to make a diagnosis. Clinicians differ more in their understanding of problems and their problem representations than in the reasoning strategies employed. This finding of case specificity challenged the hypothetico-deductive model of clinical reasoning for several reasons: both successful and unsuccessful diagnosticians used hypothesis testing, and so it was argued that diagnostic accuracy did not depend as much on strategy as on mastery of domain content. The clinical reasoning of experts in familiar situations frequently does not display explicit hypothesis testing,5,21–23 but is instead rapid, automatic, and often non-verbal. The speed, efficiency, and accuracy of experienced clinicians suggests that they might not even use the same reasoning processes as novices, and that experience itself might make hypothesis testing unnecessary. Pattern recognition implies that clinical reasoning is rapid, difficult to verbalise, and has a perceptual component. Thinking of diagnosis as fitting a case into a category brings some other issues into clearer view. Two somewhat competing accounts have been offered, and research evidence supports both. Category assignment can be based on matching the case either to a specific instance – so-called instance based or exemplar based recognition – or to a more abstract prototype. In instance based recognition a new case is categorised by its resemblance to memories of instances previously seen. This model is supported by the fact that clinical diagnosis is strongly affected by context (for example the location of a skin rash on the body), even when this context is normatively irrelevant. The prototype model holds that clinical experience – augmented by teaching, discussion, and the entire round of training – facilitates the construction of abstractions or prototypes. Better diagnosticians have constructed more diversified and abstract sets of semantic relations to represent the links between clinical features or aspects of the problem. The controversy about the methods used in diagnostic reasoning can be resolved by recognising that clinicians, like people generally, are flexible in approaching problems: the method selected depends upon the perceived characteristics of the problem. There is an interaction between the clinician’s level of skill and the perceived difficulty of the task. Whether a diagnostic problem is easy or difficult is a function of the knowledge and experience of the clinician who is trying to solve it. When we say that a diagnostic problem is difficult, we really mean that a significant fraction of the clinicians who encounter this problem will find it difficult, although for some it may be quite easy. Errors that can occur in difficult cases in internal medicine are illustrated and discussed by Kassirer and Kopelman. Many diagnostic problems are so complex that the correct solution is not contained within the initial set of hypotheses. Restructuring and reformulating occur as data are obtained and the clinical picture evolves. However, as any problem solver works with a particular set of hypotheses, psychological commitment takes place and it becomes more difficult to restructure the problem. This phenomenon has been demonstrated experimentally in a non-clinical context: recall of the details of the layout of a house varies depending on whether one takes the perspective of a burglar or a potential buyer. However, the complaint of many medical educators that students who can solve problems in the classroom setting appear to be unable to do so in the clinic with real patients, illustrates the role of social context in facilitating or hampering access to the memory store.